2019 WHO 5th 乳腺肿瘤分类
📕乳腺上皮源性肿瘤
良性上皮增生和前驱病变(Benign epithelial proliferations and precursors)
- 普通型导管上皮增生(Usual ductal hyperplasia)
- 柱状细胞病变,包括扁平上皮非典型(Columnar cell lesions, including flat epithelial atypia)
- 非典型导管增生(Atypical ductal hyperplasia)
腺病和良性硬化性病变(Adenosis and benign sclerosing lesions)
- 硬化性腺病(Sclerosing adenosis)
- 8401/0 大汗腺腺病(Apocrine adenoma)
- 微腺腺病(Microglandular adenosis)
- 放射状瘢痕/复杂性硬化性病变(Radial scar / complex sclerosing lesion)
腺瘤(Adenomas)
- 8211/0 小管腺瘤,非特指(Tubular adenoma NOS)
- 8204/0 泌乳性腺瘤(Lactating adenoma )
- 8503/0 导管腺瘤,非特指型(Duct adenoma NOS)
上皮肌上皮肿瘤(Epithelial-myoepithelial tumours)
- 8940/0 多形性腺瘤(Pleomorphic adenoma)
- 8983/0 腺肌上皮瘤,非特指型(Adenomyoepithelioma NOS)
- 8983/3 腺肌上皮瘤伴癌(Adenomyoepithelioma with carcinoma)
- 8562/3 上皮肌上皮癌(Epithelial-myoepithelial carcinoma)
乳头状肿瘤(Papillary neoplasms)
- 8503/0 导管内乳头状瘤(Intraductal papilloma)
- 8503/2 乳头状导管原位癌(Ductal carcinoma in situ, papillary)
- 8504/2 包裹性乳头状癌(Encapsulated papillary carcinoma)
- 8504/3 包裹性乳头状癌伴浸润(Encapsulated papillary carcinoma with invasion)
- 8509/2 原位实性乳头状癌(Solid papillary carcinoma in situ)
- 8509/3 实性乳头状癌伴浸润(Solid papillary carcinoma with invasion)
- 8503/3 导管内乳头状腺癌伴浸润(Intraductal papillary adenocarcinoma with invasion)
非浸润性小叶性肿瘤(Non-invasive lobular neoplasia)
- 非典型小叶增生(Atypical lobular hyperplasia)
- 8520/2 小叶原位癌,非特指型(Lobular carcinoma in situ NOS)
经典型小叶原位癌(Classic lobular carcinoma in situ)
旺炽性小叶原位癌(Florid lobular carcinoma in situ)
- 8519/2 多形性小叶原位癌(Lobular carcinoma in situ, pleomorphic)
导管原位癌(Ductal carcinoma in situ (DCIS))
- 8500/2 导管内癌,非浸润性,非特指(Intraductal carcinoma, non-infiltrating, NOS )
低核级导管原位癌(DCIS of low nuclear grade)
中核级导管原位癌(DCIS of intermediate nuclear grade)
高核级导管原位癌(DCIS of high nuclear grade)
浸润性乳腺癌(Invasive breast carcinoma)
- 8500/3 浸润性导管癌,非特指型(Infiltrating duct carcinoma NOS )
- 8290/3 嗜酸细胞癌(Oncocytic carcinoma)
- 8314/3 富于脂质癌(Lipid-rich carcinoma)
- 8315/3 富于糖原癌(Glycogen-rich carcinoma)
- 8410/3 皮脂腺癌(Sebaceous carcinoma)
- 8520/3 小叶癌,非特指(Lobular carcinoma NOS)
- 8211/3 小管癌(Tubular carcinoma)
- 8201/3 筛状癌,非特指(Cribriform carcinoma NOS)
- 8480/3 黏液癌(Mucinous adenocarcinoma)
- 8470/3 黏液性囊腺癌,非特指(Mucinous cystadenocarcinoma NOS)
- 8507/3 浸润性微乳头状癌(Invasive micropapillary carcinoma of breast)
- 8401/3 大汗腺腺癌(Apocrine adenocarcinoma)
- 8575/3 化生性癌,非特指(Metaplastic carcinoma NOS )
少见和涎腺型癌(Rare and salivary gland-type tumours )
- 8550/3 腺泡细胞癌(Acinar cell carcinoma)
- 8200/3 腺样囊性癌(Adenoid cystic carcinoma)
经典型腺样囊性癌(Classic adenoid cystic carcinoma)
实性基底样腺样囊性癌(Solid-basaloid adenoid cystic carcinoma)
腺样囊性癌伴高级别转化(Adenoid cystic carcinoma with high-grade transformation)
- 3502/3 分泌性癌(Secretory carcinoma)
- 8430/3 粘液表皮样癌(Mucoepidermoid carcinoma)
- 8525/3 多形性腺癌(Polymorphous adenocarcinoma)
- 8509/3 高细胞癌伴极向反转(Tall cell carcinoma with reversed polarity)
神经内分泌肿瘤(Neuroendocrine neoplasms)
- 8240/3 神经内分泌肿瘤,非特指(Neuroendocrine tumour NOS)
- 8240/3 神经内分泌肿瘤,G1(Neuroendocrine tumour, grade 1)
- 8249/3 神经内分泌肿瘤,G2( Neuroendocrine tumour, grade 2)
- 8246/3 神经内分泌癌,非特指(Neuroendocrine carcinoma NOS)
- 8041/3 小细胞神经内分泌癌(Neuroendocrine carcinoma, small cell)
- 8013/3 大细胞神经内分泌癌(Neuroendocrine carcinoma, large cell)
📒乳腺纤维上皮性肿瘤和错构瘤
- 错构瘤(Hamartoma )
- 9010/0 纤维腺瘤,非特指(Fibroadenoma NOS )
- 9020/1 叶状肿瘤,非特指(Phyllodes tumor NOS)
导管周间质肿瘤(Periductal stromal tumor)
- 9020/0 良性叶状肿瘤(Phyllodes tumor,benign)
- 9020/1 交界性叶状肿瘤(Phyllodes tumor,borderline)
- 9020/3 恶性叶状肿瘤(Phyllodes tumor,malignant)
📓乳腺乳头肿瘤
- 8407/0 汗管瘤,非特指(Syringoma NOS)
- 8506/0 乳头腺瘤(Adenoma of nipple)
- 8540/3 乳腺Paget病(Paget disease of breast)
📔乳腺间叶性肿瘤
血管肿瘤(Vascular tumours)
- 9120/0 血管瘤,非特指(Haemangioma NOS)
小叶旁血管瘤(Perilobular haemangioma)
静脉血管瘤(Venous haemangioma)
海绵状血管瘤(Cavernous haemangioma)
毛细血管瘤(Capillary haemangioma)
- 血管瘤病(Angiomatosis)
普通型血管瘤病(Usual angiomatosis)
毛细血管瘤病(Capillary angiomatosis)
- 9126/0 非典型血管病变(Atypical vascular lesion)
淋巴性非典型脉管病变,类似淋巴管瘤(Lymphatic atypical vascular lesion, resembling Iymphangioma)
血管性非典型脉管病变,类似淋巴管血管瘤或鞋钉样血管瘤(Vascular atypical vascular lesion, resembling haemangioma or hobnail haemangioma)
- 9120/3 放射后血管肉瘤(Postradiation angiosarcoma)
上皮样血管肉瘤(Epithelioid angiosarcoma)
- 9120/3 血管肉瘤(Angiosarcoma)
上皮样血管肉瘤(Epithelioid angiosarcoma)
纤维母细胞和肌纤维母细胞肿瘤(Fibroblastic and myofibroblastic tumours)
- 8828/0 结节性筋膜炎(Nodular fasciitis)
- 8825/0 肌纤维母细胞瘤(Myofibroblastoma)
- 8821/1 韧带样纤维瘤病(Desmoid-type fibromatosis)
- 8825/1 炎性肌纤维母细胞肿瘤(Inflammatory myofibroblastic tumour)
上皮样炎性肌纤维母细胞肉瘤(Epithelioid inflammatory myofibroblastic sarcoma)
外周神经鞘肿瘤(Peripheral nerve sheath tumours)
- 9560/0 神经鞘瘤,非特指(Schwannoma NOS)
富于细胞神经鞘瘤(Cellular schwannoma)
上皮样神经鞘瘤(Epithelioid schwannoma)
丛状神经鞘瘤(Plexifom schwannoma)
色素性神经鞘瘤(Melanotic schwannoma)
- 9540/0 神经纤维瘤,非特指(Neurofibroma NOS)
弥漫性神经纤维瘤(Diffuse neurofibroma)
非典型神经纤维瘤(Atypical neurofibroma)
丛状神经纤维瘤(Plexiform neurofibroma)
- 9580/0 颗粒细胞瘤,非特指(Granular cell tumour NOS)
- 9580/3 恶性颗粒细胞瘤(Granular cell tumour, malignant)
平滑肌肿瘤(Smooth muscle tumours)
- 8890/0 平滑肌瘤,非特指(Leiomyoma NOS)
皮肤平滑肌瘤(Cutaneous (pilar) leiomyoma)
乳头/乳晕平滑肌瘤(Leiomyoma of the nipple/areola (muscularis mamillae and areolae))
乳腺实质平滑肌瘤(Leiomyoma of the breast parenchyma)
- 8890/3 平滑肌肉瘤,非特指(Leiomyosarcoma NOS)
脂肪肿瘤(Adipocytic tumours)
- 8850/0 脂肪瘤,非特指(Lipoma NOS)
- 8861/0 血管脂肪瘤,非特指(Angiolipoma NOS)
- 8850/3 脂肪肉瘤,非特指(Liposarcoma NOS)
其它间叶性肿瘤及瘤样病变(Other mesenchymal tumours and tumour-like conditions)
- 假血管瘤样间质增生(Pseudoangiomatous stromal hyperplasia)
📗乳腺淋巴造血肿瘤分类
- 9699/3 黏膜相关淋巴组织淋巴瘤(Mucosa-associated lympoid tissue lymphoma)
- 9090/3 滤泡性淋巴瘤,非特指(Follicular lymphoma NOS)
- 9680/3 弥漫性大B细胞淋巴瘤,非特指(Diffuse large B-cell lymphoma NOS)
- 9687/3 Burkitt淋巴瘤,非特指/急性白血病,Burkitt型(Burkitt lymphoma NOS/ Acute leukemia,Burkitt type)
地方性Burkitt淋巴瘤(Endemic Burkitt lymphoma)
散发性Burkitt淋巴瘤(Sporadic Burkitt lymphoma)
免疫缺陷相关性Burkitt淋巴瘤(Immunodeficiency-associated Burkitt lymphoma)
- 9715/3 乳腺植入物相关的间变性大细胞淋巴瘤(Breast implant-associated anaplastic large cell lymphoma)
📘男性乳腺肿瘤分类
- 男性乳腺发育(Gynaecomastia)
旺炽性男性乳腺发育(Florid gynaecomastia)
纤维性男性乳腺发育(Fibrous gynaecomastia)
- 8500/2 导管内癌,非浸润性,非特指(Intraductal carcinoma,non-infiltrating,NOS)
导管原位癌(Ductal carcinoma in situ)
小叶原位癌(Lobular carcinoma in situ)
乳头Paget病(Paget disease of the nipple)
- 8500/3 浸润性导管癌,非特指(Infiltrating duct carcinoma NOS)
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